Abstract
Quinolones without the usual 6-fluorine substituent have been recently described as potent antibacterial agents. A series of non-fluorinated analogues of the antibacterial quinolone Levofloxacin were synthesized and tested.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / pharmacology
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Bacteria / drug effects*
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology
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Escherichia coli / drug effects
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Levofloxacin*
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Microbial Sensitivity Tests
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Molecular Conformation
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Ofloxacin / analogs & derivatives*
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Ofloxacin / chemical synthesis*
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Ofloxacin / pharmacology
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Structure-Activity Relationship
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Topoisomerase II Inhibitors
Substances
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Anti-Infective Agents
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Enzyme Inhibitors
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Topoisomerase II Inhibitors
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Levofloxacin
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Ofloxacin